Staphylococcus epidermidis, a commensal bacteria that inhabits healthy human skin and mucous membranes, is the cause of healthcare-associated infections. The ability of S. epidermidis to form biofilm on medical devices is the foremost virulence factor, which contributes to the reduced antibiotics efficiency, evasion from the host immune system response and the recurrence of biofilm-related infections. The bacterial biofilm harbours different subpopulations, such as viable but non-culturable (VBNC) cells, which are known to arise in adverse environmental conditions. CodY, a transcription regula ...