Publications in International Journals / Series (Article (International))

Isolation and characterisation of novel lytic bacteriophages for therapeutic applications in biofilm-associated prosthetic joint infections

  • Burton, Nathan J.; Melo, Luís D.R.; Tadesse, Michael F.D.; Pearce, Bethany; Vryonis, Evangelos; Sagona, Antonia P.

Publisher: Oxford University Press

Abstract

Prosthetic joint infections are devastating complications of joint arthroplasties. Without effective management, they can lead to limb amputation and even death. A significant proportion of these infections is caused by the primarily commensal Coagulase-negative Staphylococci pathogens, which form thick, antibiotic-resistant biofilms at the site of infection. Combinatorial therapy involving antibiotics and bacteriophages may represent a strategy to overcome resistance. Previous research indicates that as bacteria develop resistance to antibiotics, they often become more susceptible to bacterio ...

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