Conference Proceedings (Abstracts in Conference Proceedings)
Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages
- Cerca, F.; Andrade, F.; França, Ângela; Bonifácio, E.; Ribeiro, A.; Almeida, A.; Cerca, Nuno; Pier, G.B.; Azeredo, Joana; Vilanova, M.
- MicroBiotec'11 - Congress of Microbiology and Biotechnology 2011 (Book of Abstracts). Braga, Portugal, 1-3 December, 2011. ISBN: 978-989-97478-1-4
Abstract
Staphylococcus epidermidisis an opportunistic pathogen due to its ability to establish biofilms on indwelling medical devices. The presence of high amounts of dormant bacteria is a hallmark of biofilms, making them more tolerant to antimicrobials and to the host immune response. We observed that S. epidermidis biofilms grown in excess glucose accumulated high amounts of viable but non-culturable (VBNC) bacteria, as assessed by their low ratio of culturable bacteria over the number of viable bacteria. This effect, which was a consequence of the accumulation of acidic compounds due to glucose me ...
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