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PhageDPO: A machine-learning based computational framework for identifying phage depolymerases

Publisher: Elsevier

Abstract

Bacteriophages (phages) are the most predominant and genetically diverse biological entities on Earth. Phages are viruses that infect bacteria and encode numerous proteins with potential biotechnological application. However, most phage-encoded proteins remain functionally uncharacterized. Depolymerases (DPOs) in particular, enzymes that degrade external polysaccharide structures, have garnered increasing interest from both fundamental research standpoint and for biotechnological applications to control bacterial pathogens. Despite the proliferation of identification tools for predicting DPOs ...

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