Centre of Biological Engineering / Centro de Engenharia Biológica

Luís Melo

Assistant Professor

Research Line: Health Biotechnology and Bioengineering
Research Group: BSTeG
Lab.: Biofilm Research Laboratory Rosario Oliveira
253 601 989 (office) / 253 601 974 (lab)
lmelo@ceb.uminho.pt
https://www.ceb.uminho.pt/People/Profile/luismelo

Career

Since 2024: Assistant Professor, Universidade de Coimbra
2022 - 2024: Assistant Researcher (Non-Tenure Track), Universidade do Minho
2018 - 2022: Junior Researcher (Non-Tenure Track), Universidade do Minho
2018 - 2018: Invited Assistant Reseacher (non-tenured track), Universidade do Minho
2018 - 2018: Invited Assistant Reseacher (non-tenured track), Universidade do Minho
2016 - 2017: Invited Assistant Reseacher (non-tenured track), Universidade do Minho

Qualifications

2014: PhD Program in Biomedical Engineering, Universidade do Minho

Roles and Responsibilities

Since 2021: Member of the Scientific Steering Committee of the Research Unit, Centre of Biological Engineering

Since 2024: Professor integrated in the subunit: Centre of Biological Engineering
2018 - 2024: Interaction of bacteriophages with biofilm
2017 - 2018: SynPhage ‐ Construction of synthetic phages to combate infectous diseases
2016 - 2018: New insights on phage-biofilm interactions
2015 - 2016: New insights on phage-biofilm interactions
2010 - 2014: Staphylococcus epidermidis bacteriophages: New insights on endolysins and phage-biofilm interactions

Past Projects

Supervision of Researchers

Ana Rita Moreira Ferreira - Master Student
Cátia Canedo da Mota e Sá - PhD Student
Daniela Alexandra Coelho de Oliveira - PhD Student
Inês Catarina Reis Weijde - Master Student
Inês de Oliveira Santos - PhD Student
Maria Beatriz Afonso Sequeira Lopes - PhD Student

Recent Publications

1	Akturk, Ergun; Pinto, Graça; Ostyn, Lisa; Crabbé, Aurélie; Melo, Luís D.R.; Azeredo, Joana; Coenye, Tom Combination of phages and antibiotics with enhanced killing efficacy against dual-species bacterial communities in a three-dimensional lung epithelial model Biofilm, 9(100245), 2025
2	Sáez Moreno, David; Cunha, Joana T.; Melo, Luís D.R.; Tanaka, Kenya; Bamba, Takahiro; Hasunuma, Tomosiha; Azeredo, Joana; Domingues, Lucília CRISPR-Cas9 engineered Saccharomyces cerevisiae for endolysin delivery to combat Listeria monocytogenes Applied Microbiology and Biotechnology, 109(81), 2025
3	Mota-Sá, Cátia; Rodrigues, Cláudia; Silva, Vanessa; Azeredo, Joana; Melo, Luís D.R. Successful bacteriophage therapy of pyoderma caused by methicillin-resistant Staphylococcus pseudintermedius in a dog Veterinary Dermatology, 36(2), 227-230, 2025
4	Tasdurmazli, Semra; Cinar, Irfan; Karamese, Murat; Aksak Karamese, Selina; Cadirci, Elif; Melo, Luís D.R.; Ozbek, Tulin Exploring in vitro efficacy of rCHAPk with antibiotic combinations, and promising findings of its therapeutic potential for clinical-originated MRSA wound infection International Journal of Biological Macromolecules, 296(139630), 2025
5	Ferreira, Rute; Pinto, Graça; Presa, Eva; Oleastro, Mónica; Silva, Catarina; Vieira, Luís; Sousa, Cláudia; Pires, Diana P.; Figueiredo, Ceu; Melo, Luís D.R. Screening and in silico characterization of prophages in Helicobacter pylori clinical strains Microbes and Infection, 27(3), 105429, 2025
6	Lopes, Maria; Silva, Maria Daniela; Azeredo, Joana; Melo, Luís D.R. Coagulase-Negative Staphylococci phages panorama: Genomic diversity and in vitro studies for a therapeutic use Microbiological Research, 290(127944), 2025
7	Silva, Maria Daniela; Pinto, Graça; França, Ângela; Azeredo, Joana; Melo, Luís D.R. Phage SEP1 hijacks Staphylococcus epidermidis stationary cells’ metabolism to replicate mSystems, 9(7), e00263-24, 2024
8	Burton, Nathan J.; Melo, Luís D.R.; Tadesse, Michael F.D.; Pearce, Bethany; Vryonis, Evangelos; Sagona, Antonia P. Isolation and characterisation of novel lytic bacteriophages for therapeutic applications in biofilm-associated prosthetic joint infections Sustainable Microbiology, 1(1), qvae028, 2024
9	Akturk, Ergun; Melo, Luís D.R.; Oliveira, Hugo; Crabbé, Aurélie; Coenye, Tom; Azeredo, Joana Combining phages and antibiotic to enhance antibiofilm efficacy against an in vitro dual species wound biofilm Biofilm, 6(100147), 2023
10	da Silva, Jéssica Duarte; Bens, Lene; Santos, Adriele J. do Carmo; Lavigne, Rob; Soares, José; Melo, Luís D.R.; Vallino, Marta; Dias, Roberto Sousa; Drulis-Kawa, Zuzanna; de Paula, Sérgio Oliveira; Wagemans, Jeroen Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain Microorganisms, 11(9), 2141, 2023
11	Azinheiro, Sarah; Rodríguez-López, Pedro; Lozano-León, Antonio; Guedes, Hugo; Regal, Patricia; Franco, Carlos M.; Cepeda, Alberto; Teixeira, Pilar; Melo, Luís D.R.; Silva, Daniela; Fernández, Ana; Faria, Márcia; Roumani, Foteini; Herrera, Juan; Prado, Marta; López-Cabo, Marta; Garrido-Maestu, Alejandro Interlaboratory validation of a multiplex qPCR method for the detection of Listeria monocytogenes in a ready-to-eat seafood product Food Control, 150(109769), 2023
12	Andrade, Stephanie; Ramalho, Maria J.; Santos, Sílvio B.; Melo, Luís D.R.; Santos, Rita S.; Guimarães, Nuno; Azevedo, Nuno F.; Loureiro, Joana A.; Pereira, Maria C. Fighting methicillin-resistant Staphylococcus aureus with targeted nanoparticles International Journal of Molecular Sciences, 24(10), 9030, 2023
13	Sande, Maria G.; Ferreira, Débora; Rodrigues, Joana L.; Melo, Luís D.R.; Saragliadis, Athanasios; Linke, Dirk; Moreira, Felismina T.C.; Sales, M. Goreti F.; Rodrigues, Lígia R. Aptasensor for the detection of Moraxella catarrhalis adhesin UspA2 Bioengineering, 10(2), 178, 2023
14	da Silva, Jéssica Duarte; Melo, Luís D.R.; Santos, Sílvio B.; Kropinski, Andrew M.; Xisto, Mariana Fonseca; Dias, Roberto Sousa; da Silva Paes, Isabela; Vieira, Marcella Silva; Soares, José Júnior Ferreira; Porcellato, Davide; da Silva Duarte, Vinícius; de Paula, Sérgio Oliveira Genomic and proteomic characterization of vB_SauM-UFV_DC4, a novel Staphylococcus jumbo phage Applied Microbiology and Biotechnology, 107, 7231-7250, 2023
15	Sousa, Cláudia; Ferreira, Rute; Santos, Sílvio B.; Azevedo, Nuno F.; Melo, Luís D.R. Advances on diagnosis of Helicobacter pylori infections Critical Reviews in Microbiology, 49(6), 671-692, 2023
16	Sande, Maria G.; Ferreira, Débora; Rodrigues, Joana L.; Melo, Luís D.R.; Linke, Dirk; Silva, Carla J.; Moreira, Felismina T.C.; Sales, M. Goreti F.; Rodrigues, Lígia R. Electrochemical aptasensor for the detection of the key virulence factor YadA of Yersinia enterocolitica Biosensors-Basel, 12(8), 614, 2022
17	Ferreira, Rute; Sousa, Cláudia; Gonçalves, Raquel F.S.; Pinheiro, Ana Cristina; Oleastro, Mónica; Wagemans, Jeroen; Lavigne, Rob; Figueiredo, Ceu; Azeredo, Joana; Melo, Luís D.R. Characterization and genomic analysis of a new phage infecting Helicobacter pylori International Journal of Molecular Sciences, 23(14), 7885, 2022
18	Ribeiro, Henrique G.; Nilsson, Anna; Melo, Luís D.R.; Oliveira, Ana Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees Frontiers in Microbiology, 13(903861), 2022
19	Bispo, Mafalda; Sílvio B. Santos; Luís D. R. Melo; Azeredo, Joana; Dijl, Jan Maarten van; Rosato, Adriana E. Targeted antimicrobial photodynamic therapy of biofilm-embedded and intracellular staphylococci with a phage endolysin’s cell binding domain Microbiology Spectrum, 10(1), e01466-21, 2022
20	Pereira, Claudia; Pina, André F.; Sousa, Diana; Ferreira, Débora; Santos-Pereira, Cátia; Rodrigues, Joana L.; Melo, Luís D.R.; Sales, Goreti; Sousa, Sérgio F.; Rodrigues, Lígia R. Identification of novel aptamers targeting cathepsin B-overexpressing prostate cancer cells Molecular Systems Design & Engineering, 7, 637-650, 2022

Full List

Luís Melo

Assistant Professor

Career

Qualifications

Roles and Responsibilities

Past Projects

Supervision of Researchers

Past Supervision of Researchers

Recent Publications

Combination of phages and antibiotics with enhanced killing efficacy against dual-species bacterial communities in a three-dimensional lung epithelial model

CRISPR-Cas9 engineered Saccharomyces cerevisiae for endolysin delivery to combat Listeria monocytogenes

Successful bacteriophage therapy of pyoderma caused by methicillin-resistant Staphylococcus pseudintermedius in a dog

Exploring in vitro efficacy of rCHAPk with antibiotic combinations, and promising findings of its therapeutic potential for clinical-originated MRSA wound infection

Screening and in silico characterization of prophages in Helicobacter pylori clinical strains

Coagulase-Negative Staphylococci phages panorama: Genomic diversity and in vitro studies for a therapeutic use

Phage SEP1 hijacks Staphylococcus epidermidis stationary cells’ metabolism to replicate

Isolation and characterisation of novel lytic bacteriophages for therapeutic applications in biofilm-associated prosthetic joint infections

Combining phages and antibiotic to enhance antibiofilm efficacy against an in vitro dual species wound biofilm

Isolation and characterization of the acadevirus members BigMira and MidiMira infecting a highly pathogenic Proteus mirabilis strain

Interlaboratory validation of a multiplex qPCR method for the detection of Listeria monocytogenes in a ready-to-eat seafood product

Fighting methicillin-resistant Staphylococcus aureus with targeted nanoparticles

Aptasensor for the detection of Moraxella catarrhalis adhesin UspA2

Genomic and proteomic characterization of vB_SauM-UFV_DC4, a novel Staphylococcus jumbo phage

Advances on diagnosis of Helicobacter pylori infections

Electrochemical aptasensor for the detection of the key virulence factor YadA of Yersinia enterocolitica

Characterization and genomic analysis of a new phage infecting Helicobacter pylori

Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees

Targeted antimicrobial photodynamic therapy of biofilm-embedded and intracellular staphylococci with a phage endolysin’s cell binding domain

Identification of novel aptamers targeting cathepsin B-overexpressing prostate cancer cells

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Luís Melo

Assistant Professor

Career

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Supervision of Researchers

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Recent Publications

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