Publications in International Journals / Series (Conference Paper (International))

Random sampling of elementary flux modes in large-scale metabolic networks

Publisher: OUP

Abstract

Motivation: The description of a metabolic network in terms of elementary (flux) modes (EMs) provides an important framework for metabolic pathway analysis. However, their application to large networks has been hampered by the combinatorial explosion in the number of modes. In this work, we develop a method for generating random samples of EMs without computing the whole set. Results: Our algorithm is an adaptation of the canonical basis approach, where we add an additional filtering step which, at each iteration, selects a random subset of the new combinations of modes. In order to obtain an ...

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Web of Science® Citations: 29

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