Publications in International Journals / Series (Article (International))
A genome-scale metabolic model for the human pathogen Candida parapsilosis and early identification of putative novel antifungal drug targets
- Viana, Romeu; Couceiro, Diogo; Carreiro, Tiago; Dias, Oscar; Rocha, Isabel; Teixeira, Miguel Cacho
- Genes, 13(2), 303, 2022
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Candida parapsilosis is an emerging human pathogen whose incidence is rising worldwide, while an increasing number of clinical isolates display resistance to first-line antifungals, demanding alternative therapeutics. Genome-Scale Metabolic Models (GSMMs) have emerged as a powerful in silico tool for understanding pathogenesis due to their systems view of metabolism, but also to their drug target predictive capacity. This study presents the construction of the first validated GSMM for C. parapsilosis—iDC1003—comprising 1003 genes, 1804 reactions, and 1278 metabolites across four co ...
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