Publications in International Journals / Series (Article (International))
Modelling aptamers with nucleic acid mimics (NAM): From sequence to three-dimensional docking
- Oliveira, Ricardo; Pinho, Eva; Sousa, Ana Luísa; Dias, Oscar; Azevedo, Nuno Filipe; Almeida, Carina
- PLoS One, 17(3), e0264701, 2022
Publisher: Public Library of Science
Abstract
Aptamers are single-stranded oligonucleotides, formerly evolved by Systematic Evolution of Ligands by EXponential enrichment (SELEX), that fold into functional three-dimensional structures. Such conformation is crucial for aptamers’ ability to bind to a target with high affinity and specificity. Unnatural nucleotides have been used to develop nucleic acid mimic (NAM) aptamers with increased performance, such as biological stability. Prior knowledge of aptamer-target interactions is critical for applying post-SELEX modifications with unnatural nucleotides since it can affect aptamers’ structure ...
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