Publications in International Journals / Series (Article (International))
Exploiting the anti-biofilm effect of the engineered phage endolysin PM-477 to disrupt in vitro single- and dual-species biofilms of vaginal pathogens associated with bacterial vaginosis
- Castro, Joana; Sousa, Lúcia G.V.; França, Ângela; Tisakova, Lenka Podpera; Corsini, Lorenzo; Cerca, Nuno
- Antibiotics-Basel, 11(5), 558, 2022
Publisher: MDPI AG
Abstract
Bacterial vaginosis (BV) is the most frequent vaginal infection in women of reproductive age. It is caused by the overgrowth of anaerobic vaginal pathogens, such as Gardnerella vaginalis, Fannyhessea vaginae, and Prevotella bivia, which are vaginal pathogens detected during the early stages of incident BV and have been found to form multi-species biofilms. Treatment of biofilm-associated infections, such as BV, is challenging. In this study, we tested the role of an investigational engineered phage endolysin, PM-477, in the eradication of dual-species biofilms composed of G. vaginalis–F. ...
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